After two and a half years of investigation and theories about her daughter's disappearance, what does Beth believe happened to Natalee?

Beth: "We've been really careful in trying not to speculate too much. But when I go back to the facts—and the facts are, these are the last three men that were known to be seen with Natalee alive. And we do know the condition that she was in when she got into the … car. And we know the conduct they engaged in with her. After that, we have … different stories of what they gave to interrogators to explain what they did with her that night."

Oprah: "Do you still believe Joran and the Kalpoe brothers had something to do with your daughter's disappearance?"

Beth: " … I mean, when we look back, we've really tried to look outside of the circle of these three suspects. There have been, I think, close to a dozen men that have been arrested and questioned and released. So everything keeps coming back to the original three that she was last seen leaving the establishment with."

Oprah: "Joran van der Sloot and the Kalpoe brothers have always, as we know, maintained their innocence."

At one point, van der Sloot said he welcomed an opportunity to talk to Beth, but that hasn't happened. "I think the only way that could be productive is if he were hooked to a polygraph machine," Beth says. "Because we really want to get the truth."

When van der Sloot and his parents were interviewed on a Dutch talk show in January 2008, crime reporter Peter R. DeVries challenged them with some tough and heated questions about the Holloway case. After the show, van der Sloot was caught on tape throwing a glass of wine across a table into Peter's face.